Spravato® (esketamine) is an FDA-approved prescription nasal spray designed specifically for adults struggling with treatment-resistant depression or major depression with active suicidal thoughts. Unlike traditional oral antidepressants that can take 4 to 6 weeks to show any effect, Spravato works on a different pathway in the brain (targeting chemical messengers called glutamate) to help rebuild neural connections. Administered in our comfortable, supervised office setting alongside an oral antidepressant, it can begin relieving severe depressive symptoms in as little as a few hours or days—offering new hope to those who feel like they have exhausted every other option.